Trace amine associated receptor 1: predicted effects of single nucleotide variants on structure-function in geographically diverse populations

HIGHLIGHTS

• What: The authors aimed to characterise the distribution of TAAR1 SNVs in five different WHO regions using the Database of Genotypes and Phenotypes (dbGaP) and conducted a critical computational analysis using available TAAR1 structural data to identify SNVs affecting ligand binding and/or functional regions. The analysis shows 19 orthosteric 9 signalling and 16 micro-switch SNVs hypothesised to critically influence the agonist induced TAAR1 activation. TAAR1 has arisen as the major focus of TAAR research due to its therapeutic potential in treating CNS and metabolic disorders . Initial reports suggested a high placebo effect masking the therapeutic . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or Email

  Password

  Remember me

  Lost your password?

  If you don't have an account, you can create one here.