Jib-04, a pan-inhibitor of histone demethylases, targets histone-lysine-demethylase-dependent akt pathway, leading to cell cycle arrest and inhibition of cancer stem-like cell properties in hepatocellular carcinoma cells

HIGHLIGHTS

• who: Jina Lee and collaborators from the Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University have published the research: JIB-04, a Pan-Inhibitor of Histone Demethylases, Targets Histone-Lysine-Demethylase-Dependent AKT Pathway, Leading to Cell Cycle Arrest and Inhibition of Cancer Stem-Like Cell Properties in Hepatocellular Carcinoma Cells, in the Journal: (JOURNAL)
• what: The authors investigate the effect of JIB-04 on the maintenance of liver CSCs and the malignancy of HCC cells. The authors focused on the CD133+ /CD13+ population in HCC cells, as CD133+ /CD13+ hepatocytes . . .
  

   

  

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