HIGHLIGHTS
- who: Jorge Franco et al. from the Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy have published the Article: Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors, in the Journal: Pharmaceuticals 2022, 15, 855. of /2022/
- what: 2-HNA was used throughout the study as a positive control in the cell viability assay and any test compound resembling its activity was considered a potential NAPRT inhibitor. Since NAD depletion emerged as a promising anticancer strategy, most of the research has focused on disabling the nicotinamide salvage_pathway, which overall represents . . .
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