Loss of function of the mitochondrial peptidase pitrm1 induces proteotoxic stress and alzheimer⠒s disease-like pathology in human cerebral organoids

HIGHLIGHTS

• who: María José Pérez from the Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany have published the article: Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer⠒s disease-like pathology in human cerebral organoids, in the Journal: (JOURNAL)
• what: The authors provide evidence of a protective role of UPRmt and mitochondrial clearance against impaired mitochondrial presequence processing and proteotoxic stress. The authors propose a novel concept of PITRM1-linked neurological syndrome whereby defects of mitochondrial presequence processing induce an . . .
  

   

  

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