HIGHLIGHTS
- who: Kojiro Mukai from the Department Tohoku University, Sendai, Japan have published the paper: Homeostatic regulation of STING by retrograde membrane traffic to the ER, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors show that the disease-causing COPA variants prevent STING transport to the ER, leading to cGAS-independent activation of the STING pathway. The authors demonstrate the homeostatic regulation of STING at the resting state by the retrograde membrane traffic.
- how: MS and MS/MS data were obtained with TOP10 method.
SUMMARY
After STING binding . . .
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