HIGHLIGHTS
- who: Adam G. Grieve from the Dunn School University of Oxford, Oxford, RE, UK have published the Article: Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation, in the Journal: (JOURNAL)
- what: The authors show that RHBDL2 prevents stochastic calcium signaling unstimulated cells through conformational surveillance and cleavage of inappropriately activated Orai1. The authors propose that this surveillance function may represent an ancient activity of rhomboid proteases degrading unwanted signaling proteins. The authors show that proteolysis of Orai1 by RHBDL2 sharpens the precision of SOCE by preventing stimulus-independent CRAC . . .
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