In search of small molecule inhibitors targeting the flexible ck2 subunit interface

HIGHLIGHTS

  • who: Benoît Bestgen et al. from the Biology of Cancer and Infection, University Grenoble-Alpes (UGA), Grenoble, France have published the paper: In Search of Small Molecule Inhibitors Targeting the Flexible CK2 Subunit Interface, in the Journal: (JOURNAL)
  • what: The authors focused the attention on the CK2α/CK2β interface , which is relatively small (832 Å2 ), and harboring a suitable binding pocket for small_molecules . This analysis showed that, subunits in WT and with CK2β-depleted evaluated by Western blot.changed This analysis after an 8 h-treatment TAT-Pc 13, MCF-10A the level ofcells . . .

     

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