Tuning the allosteric regulation of artificial muscarinic and dopaminergic ligand-gated potassium channels by protein engineering of g protein-coupled receptors

HIGHLIGHTS

• who: Christophe J. Moreau and collaborators from the UnivGrenoble Alpes, Grenoble, France. University of have published the article: Tuning the allosteric regulation of artificial muscarinic and dopaminergic ligand-gated potassium channels by protein engineering of G protein-coupled receptors, in the Journal: Scientific Reports Scientific Reports
• what: This study demonstrats the role of the M2 and D2 C-terminus length in the regulation of the Kir6.2 gating within ICCRs.

SUMMARY

The regulation of Kir6.2 gating is inverted by truncation of the M2 C-terminus. To determine whether the difference . . .

 



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