The role of hypoxia inducible factor-1 in hepatocellular carcinoma

HIGHLIGHTS

  • who: Dongjun Luo and colleagues from the Department of Hepatobiliary Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, Jiangsu, China have published the research: The Role of Hypoxia Inducible Factor-1 in Hepatocellular Carcinoma, in the Journal: (JOURNAL) of 22/03/2014

SUMMARY

    Hypoxia inducible factor-1 (HIF-1) is the first identified mediator of cell response to hypoxia in mammalian cells cultured under reduced oxygen tension. This transcription factor is a heterodimer composed of two subunits: an oxygen-sensitive HIF-1? and a constitutively expressed HIF-1? which . . .

     

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