Extension of chronological lifespan by hexokinase mutation in kluyveromyces lactis involves increased level of the mitochondrial chaperonin hsp60

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• who: Pharmacology from the of Genetics, University of Parma, Parco Area delle Scienze, A, Parma, Italy have published the research work: Extension of Chronological Lifespan by Hexokinase Mutation in Kluyveromyces lactis Involves Increased Level of the Mitochondrial Chaperonin Hsp60, in the Journal: (JOURNAL) of 18/Nov/2011
• what: The authors report here that only the absence of the unique hexokinase, encoded by RAG5 gene, extends CLS in a CR-independent manner, indicating a specific role of this protein in reducing lifespan independently of glucose repression. Since mitochondrial damage, exerted by ROS accumulation, represents one of . . .
  

   

  

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