Induction of anergic or regulatory tumor-specific cd4+ t cells in the tumor-draining lymph node

HIGHLIGHTS

• who: Ruby Alonso from the , PSL University have published the Article: Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors use an improved lentivirus (LV) based genetically engineered lung adenocarcinoma model to characterize the fate of naive CD4+ T_cells following the recognition of a tumor-specific cytoplasmic Ag. The authors demonstrate that tumors may set a dominant inhibitory environment in the TdLN, preventing efficient priming of tumor Ag-specific naive CD4+ T_cells that instead become anergic or pTregs . . .
  

   

  

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