Adenovirus encoding tumor necrosis factor alpha and interleukin 2 induces a tertiary lymphoid structure signature in immune checkpoint inhibitor refractory head and neck cancer

HIGHLIGHTS

• who: James H. A. Clubb from the University of Florida, United States have published the research work: Adenovirus Encoding Tumor Necrosis Factor Alpha and Interleukin 2 Induces a Tertiary Lymphoid Structure Signature in Immune Checkpoint Inhibitor Refractory Head and Neck Cancer, in the Journal: (JOURNAL)
• what: The authors demonstrate that combinatorial treatment with anti-PD-1 or anti-PD-L1 blocking mAb and non-replicative Ad5-CMV-mTNFa/mIL-2 improves the anti-tumor activity of the intratumoral immune compartment in the context of HNSCC.
• how: The authors employed a highly immunogenic (MOC1 . . .
  

   

  

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