Hiv-1 tat: its dependence on host factors is crystal clear

HIGHLIGHTS

  • who: Iván D’Orso from the Department of Biochemistry and Biophysics, University of California, , th Street have published the article: HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear, in the Journal: Viruses 2010, 2, 2226-2234 of /2010/
  • future: Structural and functional studies will be needed to illuminate how the inhibitory 7SK snRNP complex is assembled into Tat complexes disassembled by Tat or ejected upon TAR binding .

SUMMARY

    HIV-1, like many viruses, co-opts the cellular machinery to orchestrate its life cycle, including its transcriptional program . . .

     

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