Synthesis and early development of hexadecyloxypropyl-cidofovir: an oral antipoxvirus nucleoside phosphonate

HIGHLIGHTS

  • who: Karl Y. Hostetler from the Department of Medicine, Division of Infectious Disease, University of California, San Diego, Veterans Medical Research Foundation, San Diego, CA, USA have published the research: Synthesis and Early Development of Hexadecyloxypropyl-cidofovir: An Oral Antipoxvirus Nucleoside Phosphonate, in the Journal: Viruses 2010, 2, 2213-2225 of 26/08/2010
  • what: HDP-CDV is a novel ether lipid antiviral which is orally active and lacks the nephrotoxicity of CDV itself.
  • how: With PCV in_vitro data showed that HDP-P-PCV was somewhat less potent than PCV against HSV-1 . . .

     

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