Crystallization of apoa1 and apoe4 nanolipoprotein particles and initial xfel-based structural studies

HIGHLIGHTS

  • who: Megan L. Shelby and colleagues from the Department of Chemical Engineering, University of California at Davis, Davis, CA, USA have published the article: Crystallization of ApoA1 and ApoE4 Nanolipoprotein Particles and Initial XFEL-Based Structural Studies, in the Journal: (JOURNAL)
  • how: The authors implemented a fixed target sample delivery scheme utilizing the Roadrunner fast-scanning system and ultra-thin polymer/graphene support films providing a low-volume low-background approach to membrane protein SFX.

SUMMARY

    Nanolipoprotein particles (NLPs), or "nanodiscs", are nanoscale complexes with apolipoproteins forming a corralled, discoidal bilayer . . .

     

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