Molecular features of the measles virus viral fusion complex that favor infection and spread in the brain

HIGHLIGHTS

• who: Cyrille Mathieu and collaborators from the WPaul, University of of Physicians and Surgeons, New York, New York, USA have published the paper: Molecular Features of the Measles Virus Viral Fusion Complex That Favor Infection and Spread in the Brain, in the Journal: (JOURNAL) of 17/Nov/2021
• what: Using murine ex vivo organotypic brain cultures and human induced pluripotent stem cell-derived brain organoids the authors show that CNS adaptive mutations in F enhance the spread of virus ex vivo. Using metagenomic structural and biochemical approaches the authors demonstrate that altered fusion properties of . . .
  

   

  

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