HIGHLIGHTS
- who: Tatsuo Shioda from the Department of Viral Infections, Research Institute for Microbial Diseases, University, Japan have published the paper: Role of human TRIM5α in intrinsic immunity, in the Journal: (JOURNAL)
- what: VIRAL DETERMINANT OF TRIM5α SENSITIVITY To determine the CA region that interacts with TRIM5α, the authors focused on HIV-2, which highly resembles SIVmac (Hahn et_al, 2000).
- how: These data indicated that Fv1 encodes a unique inhibitor that targets the incoming viral capsid but could be saturated and overwhelmed by simultaneous challenge by multiple virion particles. These results indicated that HIV . . .
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