Deficient methylation and formylation of mt-trnamet wobble cytosine in a patient carrying mutations in nsun3

HIGHLIGHTS

• who: Lindsey Van Haute from the University of Cambridge, Tennis Court Road, Cambridge , QR, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und have published the paper: Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 30/06/2016
• what: The authors show that NSun3 is required for deposition of m5C at the anticodon loop in the mitochondrially encoded transfer RNA methionine (mt-tRNAMet). The authors demonstrate that m5C deficiency in mt-tRNAMet results in the lack of 5 . . .
  

   

  

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