HIGHLIGHTS
- who: De-Li Shi from the Developmental Biology Laboratory, CNRS-UMR, IBPS, Sorbonne University, Paris, France have published the research: Decoding Dishevelled-Mediated Wnt Signaling in Vertebrate Early Development, in the Journal: (JOURNAL) of 30/09/2020
SUMMARY
Upon stimulation by Wnt ligands, membrane receptors (Frizzled) and co-receptors (LRP5/6, glypican-3/4, ROR, and RYK) assemble into complexes to activate divergent pathways (Niehrs, 2012; Green et_al, 2014; Stricker et_al, 2017). The DIX domain is involved in Wnt-induced dynamic Dvl homoand hetero-oligomerization that is important for Wnt/ß-catenin signaling (Kishida . . .
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