Class iia histone deacetylase inhibition ameliorates acute kidney injury by suppressing renal tubular cell apoptosis and enhancing autophagy and proliferation

HIGHLIGHTS

• who: . and colleagues from the Chongqing Medical University, China have published the research work: Class IIa histone deacetylase inhibition ameliorates acute kidney injury by suppressing renal tubular cell apoptosis and enhancing autophagy and proliferation, in the Journal: (JOURNAL)
• what: The authors assessed the therapeutic effect of TMP269, a highly selective class IIa HDAC inhibitor, on AKI and the mechanisms involved in two murine models-the first induced by folic acid and the second by ischemia/reperfusion. The authors show that administration of TMP269 dramatically inhibited renal tubular cell apoptosis in found that blocking class IIa . . .
  

   

  

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