Knockout of vdac1 activates hypoxia-inducible factor through reactive oxygen species generation and induces tumor growth by promoting metabolic reprogramming and inflammation

HIGHLIGHTS

  • who: M. Christiane Brahimi-Horn from the Institute for Research on Cancer and Aging of Nice, CNRS-UMR, Inserm, University of Nice Sophia-Antipolis, Centre Antoine Lacassagne, Ave de Valombrose, Nice, France have published the paper: Knockout of Vdac1 activates hypoxia-inducible factor through reactive oxygen species generation and induces tumor growth by promoting metabolic reprogramming and inflammation, in the Journal: (JOURNAL)
  • what: The authors report that VDAC1 participates in apoptosis and oxidative_phosphorylation via reactive oxygen species (ROS) production, which modulates proliferation. The authors report connection to the Raf/MEK/ERK signaling pathway that counterbalances . . .

     

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