Adapting the engine to the fuel: mutator populations can reduce the mutational load by reorganizing their genome structure

HIGHLIGHTS

  • who: Jacob Pieter Rutten from the (UNIVERSITY) have published the research: Adapting the engine to the fuel: mutator populations can reduce the mutational load by reorganizing their genome structure, in the Journal: (JOURNAL)
  • what: By analyzing the genomes of the mutators the authors show that the fitness recovery is due to two mechanisms: i. an increase in robustness through compaction of the coding part of the mutator genomes ii. an increase of the selection coefficient that decreases the mean-fitness of the population. At generation 300,000, all populations are well adapted to their environment . . .

     

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