HIGHLIGHTS
- who: Silvia Venturi and collaborators from the University of Groningen have published the Article: Multienzymatic Stereoselective Reduction of Tetrasubstituted Cyclic Enones to Halohydrins with Three Contiguous Stereogenic Centers, in the Journal: (JOURNAL) of October/26,/2020
- what: Nonetheless, in this study the authors show how ene-reductases can be used as efficient catalysts for the reduction of sterically demanding substrates such as the tretrasubstituted conjugated alkenes 1a-1l . Lastly, the authors show that ERs coupled with ADHs reduce α-halo tetrasubstituted cyclic enones, affording the corresponding halohydrins in good yield and with high selectivity. elimination occurred . . .
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