Estimating constraints for protection factors from hdx-ms data

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  • who: Simon P. Skinner from the Astbury Centre for Structural Molecular Biology and School of Cellular and Molecular Biology, University of Leeds, Leeds, United Kingdom have published the Article: Estimating Constraints for Protection Factors from HDX-MS Data, in the Journal: (JOURNAL)
  • what: The authors show that if time-resolved measurements are available for a number of overlapping peptides that cover the whole sequence rate constants for each amide hydrogen exchange (or equivalently their protection factors) may be extracted and the uniqueness of the solutions obtained depending on the degree of peptide overlap. The authors . . .

     

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