Efficacy assessment of an uncharged reactivator of nop-inhibited acetylcholinesterase based on tetrahydroacridine pyridine-aldoxime hybrid in mouse compared to pralidoxime

HIGHLIGHTS

  • who: André-Guilhem Calas and collaborators from the Département de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, Paris, France have published the paper: Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime, in the Journal: (JOURNAL)
  • what: While currently available oximes are unable to reach the central nervous system to reactivate cholinesterases or to display a wide spectrum of against the variety of organophosphorus compounds the authors aim to identify new reactivators without such drawbacks. Thereafter the . . .

     

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