Tnfa/tnfr2 signaling is required for glial ensheathment at the dorsal root entry zone

HIGHLIGHTS

• who: Cody J. Smith and colleagues from the Department of Biology, University of Virginia, Charlottesville, Virginia, United States of America have published the Article: TNFa/TNFR2 signaling is required for glial ensheathment at the dorsal root entry zone, in the Journal: (JOURNAL) of March/22,/2017
• what: Using in vivo time-lapse imaging the authors show that as centrally-projecting pioneer axons from dorsal root ganglia (DRG) enter the spinal cord they initiate expression of the cytokine TNFalpha. The authors demonstrate that the cytokine tumor necrosis factor alpha (TNFa) is upregulated in pioneer axons upon . . .
  

   

  

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