Pharmacological activation of’pparβ/δ preserves mitochondrial respiratory function in ischemia/reperfusion via stim

HIGHLIGHTS

• who: Ioanna Papatheodorou from the University of Pittsburgh, United States have published the article: Pharmacological activation ofu0092PPARu03b2/u03b4 preserves mitochondrial respiratory function in ischemia/reperfusion via stim, in the Journal: (JOURNAL)
• what: This study shows that PPARb/d activation does not affect mitochondrial respiratory function under basal conditions. The aim of this study was to gain further mechanistic insights of the function of PPARb/d, a transcriptional regulator, in I/R. Given the limited time window for protective interventions during reperfusion, pretreatment with the agonist would allow adequate time for effective transcriptional activation of PPARb . . .
  

   

  

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