Regulation of the proapoptotic functions of prostate apoptosis response-4 (par-4) by casein kinase 2 in prostate cancer cells

HIGHLIGHTS

• who: A de Thonel from the University of Kentucky, Lexington, KY, USA and Anticancer Center Jean Francu00b8ois Leclerc, Dijon, France have published the research: Regulation of the proapoptotic functions of prostate apoptosis response-4 (Par-4) by casein kinase 2 in prostate cancer cells, in the Journal: (JOURNAL)
• what: The authors show that (i) benzyloxycarbonylvalyl-alanyl-aspartic acid (O-methyl)-fluoro-methylketone (zVAD-FMK), a pan inhibitor of caspases, prevents rat Par-4 cleavage, (ii) the Par-4 mutant D123A (potential rat caspase site) was not cleavable (Supplementary Figure S6a, left panel).
• how . . .
  

   

  

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