Epigenetic regulation of pancreatic adenocarcinoma in the era of cancer immunotherapy

HIGHLIGHTS

  • who: Kazumichi Kawakubo from the Department of Gastroenterology and Hepatology, Faculty of University, Sapporo, Japan have published the research: Epigenetic regulation of pancreatic adenocarcinoma in the era of cancer immunotherapy, in the Journal: (JOURNAL)

SUMMARY

    Epigenetic regulation of gene_expression includes the post-translational modification of histone proteins and methylation of DNA. Immune checkpoint inhibitors targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA4) and programmed cell death 1/programmed death ligand 1 (PD1/ PDL1) have been used with great success in several cancers and are now widely accepted as one of the standard therapies . . .

     

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