The neuroepithelial origin of ovarian carcinomas explained through an epithelial-mesenchymal-ectodermal transition enhanced by cisplatin

HIGHLIGHTS

• What: With this modification, the authors intended to stimulate the stemness in those 3D cultures. Epithelial-neuronal gene_expression and phenotypic switch in SKOV3 cells induced by cisplatin To determine the molecular basis of the morphological conversion of epithelial cancer cells into neuron-like cells under the genotoxic stress of cisplatin, the authors first conducted a gene_expression analysis focusing on markers indicative of neuronal conversion. Given the extensive data showing that ovarian cells can undergo morphological and gene_expression changes towards an ectodermal state under cisplatin exposure, the authors aimed to identify cells with distinct neuronal-related features in . . .
  

   

  

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