HIGHLIGHTS
- What: Using a preclinical model of chronic experimental asthma, the authors demonstrate that rhinovirus-induced exacerbations increase PGD2 release, mucus production, transforming growth factor (TGF)-β1 and type-2 inflammation. The authors demonstrate that DP2 antagonism resolves ASM remodelling via PGD2/DP1-mediated upregulation of IFN-γ expression, and that dual DP2 antagonism/corticosteroid therapy, as often occurred in the human trials, impairs the efficacy of DP2 antagonism by suppressing endogenous PGD2 and IFN-γ production.
- Who: Md Ashik Ullah from the (UNIVERSITY) have published the paper: Dual therapy with corticosteroid ablates the beneficial effect of DP2 . . .
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