Elucidating cancer subtypes by using the relationship between dna methylation and gene expression

HIGHLIGHTS

• What: The authors evaluate the identified subtypes using Kaplan-Meier plots and hazard ratio analysis on the three types of cancer-GBM (glioblastoma multiform) lung and colon Comparison with subtypes identified by both single- and multi-omics studies implies improved clinical association. The aim of the paper is twofold: the integration of epigenomic and transcriptomic datasets followed by subtypes in the latent space. The authors propose the use of sparse canonical correlation analysis , to combine DNA methylation and gene_expression datasets while mapping them to a lower-dimensional space. The authors report hazard ratios as well as log . . .
  

   

  

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