Genetic variation at 11q23.1 confers colorectal cancer risk by dysregulation of colonic tuft cell transcriptional activatorpou2af2

HIGHLIGHTS

  • What: The authors demonstrate that genotype at rs3087967 controls a portfolio of genes through misregulation of POU2AF2. While this analysis provides valuable insights, it is limited by some inherent sparsity in the targeted proteins tested per cell line (eg, p300 and MED1 ChIPseq not performed alongside POU2AF3, and POU2AF3 ChIPseq performed in only a single cell line).
  • Who: GI cancer and colleagues from the (UNIVERSITY) have published the Article: Genetic variation at 11q23.1 confers colorectal cancer risk by dysregulation of colonic tuft cell transcriptional activator POU2AF2, in the Journal: (JOURNAL) of 14/02/2024 . . .

     

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