HIGHLIGHTS
- What: In the present study, a global collection of complete or nearly complete ARV S1 sequences has been analyzed using a phylogenetic and phylogeographic approach to address this knowledge gap. 2). years of the study 6 of 13 A more dedicated focus on the XX century revealed that all genotype populations significantly increased until the 1970s, followed by a stationary or slight decline lasting about two decades, and a new rise thereafter. This study shows the ancient and progressively increasing unconstrained worldwide circulation of ARVs, involving all genotypes, in spite of vaccine development and application.
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