HIGHLIGHTS
- What: The authors demonstrate that single replicate transient transfections of this library can provide reliable transcription rate estimates for the episomal synthetic promoters across a range of stimuli, from heavy metal toxicity to G protein coupled receptor (GPCR) activation, and between numerous cell lines. Using this platform the authors determine the transcription factor signaling contributions of numerous GPCRs, notable drug development targets, discover distinct patterns of activity from each receptor, and derive synthetic high dynamic range reporter constructs as readouts of their signaling activity.
- Who: Adam M. Zahm from the (UNIVERSITY) have published the research . . .
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