Microglia in morphine tolerance: cellular and molecular mechanisms and therapeutic potential

HIGHLIGHTS

• What: The authors explore the signalling pathways involved in microglia associated with morphine tolerance based on existing research, and summarise the basic research available, including possible combination regimens and potential targets, in the hope of providing new ideas for clinical pain management and future research on morphine tolerance. This study shows that upstream signals of NLRP3 inflammasome include P2X7R (Cai et_al, 2016; Wang H. Frontiers in Pharmacology 3.3 P2X4 and P2X7 signaling pathways P2X4 is involved in the activation and migration of microglia and the formation of morphine tolerance, and inhibitors of the P2X4 receptor (P2X4R . . .
  

   

  

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