Retinal pigment epithelial cells reduce vascular leak and proliferation in retinal neovessels

HIGHLIGHTS

• What: The authors aimed to (I) evaluate the role of pigment plaques on vascular changes and disease progression in MacTel, and_(II) study underlying disease mechanisms using the Vldlr-/- mouse model mirroring these changes. The authors show in a longitudinal, retrospective study of eyes with MacTel that perivascular pigment accumulation was associated with reduced vascular leakage and decreased de novo formation of exudative neovascularization. Based on the findings , the authors propose Angiogenesis 28:1 that EMT of the RPE, followed by proliferation, migration and perivascular accumulation may function as a "natural repair mechanism", exerting beneficial, anti-angiogenic . . .
  

   

  

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