Systemic manifestations of copd and the impact of dual bronchodilation with tiotropium/olodaterol on cardiac function and autonomic integrity

HIGHLIGHTS

• What: The aim of the study was to evaluate the effect of short-term COPD treatment with tiotropium/olodaterol (TIO/OLO) 5/5 µg on cardiac and Methods: Twenty-nine patients with newly diagnosed moderate-to-severe COPD were enrolled. Seven were lost to follow-up or could not repeat the investigation due to personal reasons. The results of the study show that LV and RV function is significantly affected by airflow limitation and the changes in intrathoracic pressures in patients with COPD. The main reason for that is the reduction in the preload caused by intrathoracic . . .
  

   

  

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