HIGHLIGHTS
- What: The authors previously demonstrated an increase in cortical reactive oxygen species and decreased function after CPB using hyperoxic oxygen This study investigates whether controlled oxygenation (normoxia) CPB reduces cortical dysfunction and oxidative injury. The authors aim to expand upon this study by_(1) investigating the oxygenation strategy in cyanotic animals and_(2) using a survival model of CPB to better evaluate the short and long-term effects of oxygen level titration during pediatric CPB on the developing brain.
- Who: Danielle I. Aronowitz et al. from the Division of Cardiothoracic Surgery, Children`s Hospital of . . .
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