Fasciola hepatica soluble antigen (fhag)-induced nets under hypoxic conditions exert cytotoxic effects on hepatic cells in vitro

HIGHLIGHTS

• What: The aim of this study was to investigate the cytotoxic effects of Fascila hepatica-induced ovine NETs in exposed hepatocytes in vitro and to analyze whether F. antigens (FhAg) trigger the release of ovine NETs under hypoxic conditions as well as the roles of matrix metalloproteinase-9 (MMP-9) and CD11b in this cellular process in vitro. The authors demonstrate that FhAg-NETs are cytotoxic for hepatoresulted in significantly enhanced cell death (p and amp;lt; 0.0001; Figure 2B) when compared to the cytes. control. The authors demonstrate that NET formation in response to FhAg . . .
  

   

  

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