Imaging tumor and ascites-associated macrophages in a mouse model of metastatic ovarian cancer

HIGHLIGHTS

  • What: We have imaged primary tumoral TAMs with their ovarian tumors, secondary lung metastasis TAMs and activated gastrointestinal tissue-resident macrophages associated with ascites using [124I]iodo-DPA-713 PET/ MRI and DPA-713-IRDye800CW near IR fluorescence imaging.
  • Who: Macrophages and collaborators from the All surgical procedures and animal handling were performed in accordance with protocols approved by the Johns Hopkins University, Institutional Animal Care and Use Committee and Radiation Safety protocolsMurine ovarian cancer model and tumor implantation have published the Article: EJNMMI Research Imaging tumor and ascites-associated in mouse model of metastatic . . .

     

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