Retinoic acid inhibition of cell proliferation via activation of cdkn1b signaling in the forebrain and spinal cord during mouse embryonic development

HIGHLIGHTS

• What: Because the mechanism of RA`s teratogenic effects requires further study, this research investigated RA ‘s teratogenic effects on the cell cycle during cell proliferation and migration in the embryonic brain and spinal cord by manipulating CDKN1B as a cell cycle arrest gene. The study investigated the effects of retinoic acid (RA) on fetal development at gestational day (GD) 13.5. This study investigates the effects of RA during a critical period in brain development, from GD 10.5 to GD 12.5, with dissection and analysis conducted at GD 13.5. Interestingly, the research demonstrated . . .
  

   

  

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