HIGHLIGHTS
- What: For the analysis of L88/5 cells mineralized with ECM, Alizarin Red was used to dye calcium deposits on days 7, 14, and 21. The study shows that GNAS haploinsufficiency alone induces osteodifferentiation of NI cells, and_(2) the simultaneous presence of induction accelerates the process towards an OS-like phenotype. To conclude, the data represent the initial part of the research aimed at demonstrating that the inducted GNAS-silenced cells represent a reliable human in_vitro model to investigate the pathophysiology of GNAS-related ectopic ossifications in PHP, AHO, and POH.
- Who: Chandi C . . .
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