HIGHLIGHTS
- What: The authors showed that six different IFIH1 variants were detected in nine patients suffering from severe COVID-19, MIS-C, periodic fever, inflammatory bowel disease, or immunodeficiency with glomerulonephritis. The authors reported two cases with severe COVID-19 and the IFIH1 putative loss-of-function variants c.1641 + 1G > C and c.2730C > A, which are likely to impair MDA5 activation, hence disrupting type I interferon activity and reducing viral clearance leading to severe COVID-19 outcomes.
- Who: Posted Date October and colleagues from the Clinical and Laboratory Characteristics of patients with , Loss-of . . .
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