Recruitment of plasma cells from il-21-dependent and il-21-independent immune reactions to the bone marrow

HIGHLIGHTS

• What: The IL-21-mediated downregulation of CD19 expression on activated B cells implies that CD19low BMPC are derived from follicular immune reactions, while CD19high BMPC are generated in extrafollicular immune reactions in the absence of IL-21 expressing follicular T helper Here the authors provide a comprehensive single-cell gene_expression analysis of human bone marrow plasma cells (BMPC). The authors show that CD19 is downregulated by IL-21, an essential signal of follicular helper T_cells in follicular immune reactions. The authors show that distinct immune reactions, exemplified for SARS-CoV-2 spike and tetanus, are diverse . . .
  

   

  

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