Shikonin inhibits oral cancer progression through suppression of metastasis and angiogenesis and induction of autophagy and apoptosis

HIGHLIGHTS

• What: Animal xenograft experiments were conducted to examine the in vivo antitumor effects of shikonin. The aim of this study was to demonstrate the specificity of shikonin for oral cancer cells and confirm its inhibitory effect through MTT experiments. This finding suggests that shikonin effectively inhibits the migration of oral cancer cells, as depicted in Figure 2A and B. Next, the authors aimed to identify the specific protein that shikonin regulates to inhibit cancer cell migration. The authors aimed to evaluate the effects of shikonin on VEGF-A and VEGF-C expression and clarify its potential to . . .
  

   

  

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