Axons compensate for biophysical constraints of variable size to uniformize their action potentials

HIGHLIGHTS

• What: Using direct patch-clamp recordings and voltage imaging in small hippocampal axons in acute slices from rat brains the authors demonstrate that AP shapes remain uniform within the same axons even across an order of magnitude difference in caliber. The analysis showed that the integral area of APs was not correlated with bouton identity or the effective size of the recorded mossy fiber structure, measured by local capacitance (Fig 1G). Channels, the authors focused on the potential role of Kv1 channels in uniformizing single axonal APs, the authors inhibited Kv1.1 and Kv1.2 channels with . . .
  

   

  

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