Identification of isoasp7-aβ as a major aβ variant in alzheimer’s disease, dementia with lewy bodies and vascular dementia

HIGHLIGHTS

• What: The aim of this study was to test the hypothesis that distinct types of are characterized by specific patterns of post-translationally modified variants. The authors report robust and instant fibril formation without lag phase in aggregation assays. Intriguingly, targeting isoAsp7-Aβ with the monoclonal antibody K11 used in this study has already been demonstrated to reduce amyloid pathology and to ameliorate behavioural deficits in 5xFAD mice . In this study, an association between Aβ(4-X) and cored plaques, CAA and also diffuse plaques was reported in human AD brain tissue, along with an enhanced brain . . .
  

   

  

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