Lower neurovascular coupling response despite higher cerebral blood flow at rest in apolipoprotein ɛ4 positive adults

HIGHLIGHTS

• What: The aim of this study was to comprehensively evaluate the influence of the APOEε4 allele on both resting CBF and cerebrovascular function (measured by CVR and NVC) in cognitively unimpaired aging adults. Consistent with previous research, the authors report greater MCA blood flow at rest in APOEε4 + compared with APOEε4- adults . As participants recruited for this study were younger (62 ± 4 years), generally healthy, and cognitively unimpaired, the findings of this study provide insight into a critical period where clinically relevant declines in total CBF and microvascular cerebral perfusion likely begin or are . . .
  

   

  

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