Expansion of epileptogenic networks via neuroplasticity in neural mass models

HIGHLIGHTS

• What: The model highlights that synaptic plasticity at excitatory connections and structural changes in the inhibitory system can transform a healthy region into a secondary epileptic focus under recurrent seizures and interictal activity occurring in the primary focus. The authors develop a plastic neural mass model integrating physiological and pathologic plasticity. Funding: This project has received funding from the European Research Council (ERC) under the European Union`s Horizon 2020 research and innovation program (grant agreement No 855109 to FW). The aim of this article is to investigate the expansion of epileptogenic networks with a mathematical model . . .
  

   

  

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